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1 Introduction Nasal drug delivery has increasingly garnered significant attention in recent years as a non-invasive drug delivery route

Once weekly injection for optimal fat burning, energy, and appetite suppression

As a GLP-1 receptor agonist, semaglutide mimics the actions of endogenous GLP-1 but with one critical engineering advantage: while native GLP-1 has a biological half-life of only a few minutes before being cleaved by the enzyme DPP-4, semaglutide achieves a half-life of approximately seven days through structural modifications that include an Aib amino acid substitution at position 8 (blocking DPP-4 recognition) and a C18 fatty acid chain attached via a linker, which enables reversible binding to albumin in the bloodstream

Because Survodutide is still under investigation, its long-term safety profile is not fully established