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Forms thermally reversible gels that provide controlled release of encapsulated therapeutics over extended periods

The mechanism mediating the ability of PYY to regulate food intake is contentious but likely involves alterations in gastric emptying, vagal neuronal signaling to the hypothalamus 200,203,204 , and direct endocrine activation of the ARC 200

Notably, combinatorial treatment with CB-839 and mTOR inhibitors has shown synergistic effects in preclinical studies, offering a compelling rationale for dual-targeted strategies and highlighting their potential for future clinical translation (253, 254)

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