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Rigorous preclinical and clinical evaluations will be essential to determine their safety, efficacy, and potential contribution to improving reproductive outcomes in patients with DOR

One article proposed that excessive serotonin levels could explain classic symptoms of ME/CFS (433), as it would promote the release of excess CRH, and therefore cause chronic reactivation of the HPA axis (434)

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They also note milder side effects and other potential reasons for discontinuation cannot be captured fully in registries and were likely underestimated