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2025 Jul National Institutes of Health

As weight decreases, the body may produce more testosterone and estrogen, hormones vital for sexual desire

Sleep improvements noticeable within 2 weeks Mild appetite reduction begins 2 to 5 lb typical weight loss Body adapting to medications Strong appetite suppression develops Energy improvements evident 4 to 8 lb additional weight loss Exercise recovery improving Full synergistic effects active Body recomposition visible Steady 1 to 2 lb weekly loss Peak energy and recovery Beyond 16 Weeks: Maintenance and Continuation Long-term protocols vary based on individual goals and response

They also suppressed inflammation and formation of reactive oxygen species (ROS) in vasculature, resulting in vasorelaxation and amelioration of hypotension