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Only 11.2% of participants stopped the trial due to side effects, and the discontinuation rate dropped significantly after week 24, suggesting those who make it through the early phase generally tolerate it well long-term

For the most severe forms of thalassemia, hematopoietic stem-cell transplantation (HSCT) is currently the only curative therapeutic option 2, 3 with busulfan (Bu) as the key component of the myeloablative regimen prior to HSCT

[34] regarding the studied rural populations (Pruszcz Gdaski, Trbki Wielkie and Pszczki, Poland) showed that the prevalence of dementia was estimated at 6.7%

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