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The association with genetic causes is not well known, with only a few cases reported in which mutations occurred in the CDH1 (Cadherin 1) gene when appendiceal signet-ring cell adenocarcinoma was associated with gastric signet-ring cell adenocarcinoma [77], and also in the KRAS [72,78] and GNAS genes [10,72]

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Combination therapies were shown to have stronger benefits regarding most of the measured parameters [including abnormalities in aspartate aminotransferase (AST) and alanine aminotransferase (ALT) concentrations, markers of systemic inflammation (clear reductions of IL-1 levels), liver inflammation, hepatocellular oxidative stress, hepatic fibrosis and hepatocyte apoptosis] vs

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