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Compounds like PT-141 activate melanocortin receptors that influence arousal and sexual motivation before vascular changes even begin

98 Whether GHR-targeted strategies will be an effective treatment for retinopathy is still a matter of debate: a small clinical study using the GHR antagonist, pegvisomant, did not observe regression of proliferative diabetic retinopathy

These mechanisms are related, but they are not interchangeable

By addressing both the biological rationale and methodological limitations of existing studies, this review provides insight that could be used as a reference to inform clinical decision-making and support the development of robust, evidence-based guidelines for tinnitus management