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Sun R, Zhang Z, Bao R, Guo X, Gu Y, Yang W, et al

Candidates who may benefit most from combined treatment Combining semaglutide and hormone therapy is most beneficial for individuals who have struggled to lose weight through diet and exercise alone or those dealing with age-related hormonal imbalances

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Gradual dose escalation is crucial for mitigating AEs, while combination with other medications, including oral antidiabetic agents, and consideration of polypharmacy in older adults, as well as individualization of therapy, should consider comorbidities, gastrointestinal tolerability, and cost