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These melanin-independent mechanisms provide cellular UV protection additive to the physical UV-screening function of melanin , explaining why MT-1 provides photoprotection in EPP patients where the primary clinical endpoint is protection from visible light rather than UV-induced tanning

ET-1, a vasoconstrictor peptide originating from endothelial cells, exerts its effects through endothelin receptors and is correlated with cardiovascular disease severity

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Linear regression analysis (line fitting) was performed using GraphPad Prism Software (version 9.5.1) (GraphPad Software, Inc.)