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We can conclude that sulfonylureas are still the most used anti-diabetic agents: maybe this is due to their lower cost, to the possibility of mono-dosing and to the presence of an association with metformin in the same tablet

However, certain groups should exercise caution

J Nutr (2015) 145(9):204651.10.3945/jn.115.210617 39 JacknessCKarmallyWFebresGConwellIMAhmedLBesslerMet alVery low-calorie diet mimics the early beneficial effect of Roux-en-Y gastric bypass on insulin sensitivity and beta-cell function in type 2 diabetic patients

This low starting dose allows the body to adjust and minimizes side effects before escalation