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The transgene carrying this 3UTR replacement was otherwise identical to the sygl-1 transgene described above ( Fig 1C ), including insertion into the same chromosomal site and rescue of lst-1 sygl-1 double mutants from sterility to fertility ( S3A Fig )

LOXs activation can also be blocked when the cell is in a redox state, such as the activation of GPX4[102]

Some experts have cautioned against their use, pointing to concerns over incorrect dosing, potential contaminants, unintended biological effects and the lack of human testing

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