Concomitant Inhibition of NRF2/GPX4 and NRF2/Bcl2 as new therapeutic strategies in AML Liu et al., highlighted the important role of NRF2 in AML, where it is critical in detoxifying ROS in combination with GPX4

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Most patients notice meaningful appetite reduction within 1-2 weeks, but the strongest effects typically emerge around week 3-4 when steady-state medication levels are reached
Relative to the healthy control subjects, PD patients not taking medication displayed hypoactivation of the left primary motor cortex when performing the tapping task