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43,44 Collectively, these findings support the notion that brain GLP-1 receptors regulate feeding behavior and body weight, 3,20,24 complementing the limited phagocytosis of endogenous GLP-1 via peripheral receptors

Maintenance doses become impractical at this concentration

A 2024 trial showed tirzepatide reduced hospitalization for heart failure and improved quality of life scores significantly

Due to the potential loss of lean body mass with the use of GLP-1 and GIP/GLP-1 RAs, the OMA advises baseline body composition analysis with reassessment at regular intervals, if there is a substantial weight reduction in a short period of time, or if weight reduction is considered to be excessive [58,59]