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In addition, the synthetic small-molecule inducers ML162 (or DPI7), ML210 (or DPI10), the approved anticancer agent altretamine, and the new inducer FIN56 could directly act on GPX4 and suppress GPX4 activity (Weiwer et al., 2012

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After these symptoms there occurs an acute hemolysis where frequently the recount of erythrocytes falls below 1.0 x 1012/l