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The most common clinical cause for concern about a pigmented lesion is a reported changing mole. In an otherwise previously uniform symmetric nevus, such changes typically include an increase in size, the formation of irregular borders with adjacent normal skin, and a peripheral change in color

(Elsevier, 2017)

Hollmann et al., 2019), and by protecting against damage during freeze-thaw cycles (Yamashita et al., 2020)

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