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Serious but rare side effects include pancreatitis (severe abdominal pain radiating to back), gallbladder problems (upper right abdominal pain, especially after eating), kidney issues (usually from severe dehydration), severe allergic reactions (difficulty breathing, severe rash, facial swelling), and vision changes (particularly in people with diabetes)

Beyond medicines, gynaecomastia can result from physiological causes (puberty, ageing), hypogonadism , liver cirrhosis , hyperthyroidism , chronic kidney disease , or rarely testicular or adrenal tumours

SLC22A2 ) and then excreted into the tubular lumen via multidrug and toxin extrusion protein 1 (MATE1

It is a defined amino acid