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Originally developed as an anti-obesity drug, AOD-9604 is a synthetic fragment derived from human growth hormone (hGH), specifically the 177-191 amino acid sequence

The relatively low amount of free amino acids released from the yeast biomass treated by PEF 1 after 24 h of incubation (Figure 4A) seems to indicate that proteolysis did not occur or perhaps occurred to a lesser degree

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Nevertheless, in most treatment guidelines for NP, opioids (e.g., morphine and oxycodone) are only suggested for use as third-line treatment drugs because of drug safety considerations and their low analgesic effect in NP [49,52,53,54]