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One of the main causes of mtGSH depletion is impaired transport systems, as seen in alcoholic steatohepatitis (ASH) caused by excessive alcohol consumption

subsequently, excess iron generates reactive oxygen species (ROS) and activates iron-containing enzymes, causing lipid peroxidation, ultimately resulting in oxidative membrane damage (5)

Circulating iron uptake in the form of two ferric iron (Fe 3+ ) bound to transferrin (TF) is achieved by binding to transferrin receptor protein 1 (TFR1) and subsequently triggering endocytosis [70]

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