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Side Effects of Excessive B12 Intake Whilst vitamin B12 toxicity is uncommon, several adverse effects have been reported in association with very high B12 levels, though establishing direct causation remains challenging

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Somatic symptoms of anxiety related to the digestive tract activity include, among others, dry mouth, burning in the esophagus, heartburn, excessive salivation, nausea and vomiting, spastic states of the esophagus, stomach, and intestines, a feeling of discomfort in the abdominal cavity, diarrhea, functional motility disorders, swallowing problems, lack of appetite, and sometimes excessive appetite and obesity

MOTS-C is a mitochondrial-derived peptide