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Like all medications, PT-141 affects different people in different ways, and not everyone will experience the same set of benefits

The current standard operating procedure by the European Center for the Validation of Alternative Methods (ECVAM) recommends the use of MTT reduction as parameter to make prediction on the skin irritancy of substances using EpiSkin TM test method, while IL-1 endpoint is regarded as a useful adjunct to MTT assay 48

Regulatory hurdles: Approval for novel indications (Alzheimers, neurodegenerative diseases) requires very high bar: long follow-ups, clinically meaningful endpoints, safety