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Incidence Estimates A large Danish cohort study (N=25,906 isotretinoin users, follow-up through national registries) published in the BMJ (2019) found no statistically significant increase in depression diagnoses or antidepressant prescriptions after isotretinoin initiation compared with oral antibiotic controls, with a hazard ratio of 0.99 (95% CI 0.91 to 1.07)

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