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Cellular senescence mediates fibrotic pulmonary disease

The Strategic Funding Increase program was designed specifically to bridge this gap, combining government SBIR funding with private matching capital to give high-potential companies the runway to reach procurement-ready status

This regulatory status unlocked a dormant provision in the Drug Quality and Security Act (DQSA) of 2013, temporarily suspending patent enforcement and allowing outsourcing facilities to mass-produce essentially copies of these patented drugs

This includes a greater degree of left ventricular remodeling, biventricular dilatation, and higher resting and exercise filling pressures, thought to be due expanded plasma volume through a variety of pathophysiologic mechanisms