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What is NNMT and why is it a therapeutic target

If you have severe deficiency, B12 injections might be more appropriate as they have nearly 100% absorption rate

It has been found, using specific knock out (KO) mice and cultures, different specific activities for IRS-1 and IRS-2, additional further complexity comes with tissue-specific roles

Recent studies have shown high levels of vitamin B12 in the pilosebaceous follicle, and demonstrated that Vit B12 supplementation in Propionibacterium acnes colonies promotes the production of porphyrins which undergo a process of oxidation on the skin surface, release pro-inflammatory substances that ultimately favor the development of acneiform lesions [7]