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A1C reduction with Rybelsus (oral semaglutide) In one clinical study, people taking oral semaglutide daily lowered their A1C (a blood sugar test) by 1.2% over 26 weeks

Semaglutide may also slow the emptying of the stomach, leading to a prolonged sense of satiety after meals

The minor benefits of sublingual administration do not justify the typically higher cost