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A novel intellectual disability syndrome caused by GPI anchor deficiency due to homozygous mutations in PIGT

The goal is sustainable treatment, and sustainable means maintaining quality of life alongside weight loss

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Importantly, the GLP-1R-cholesterol binding sites identified here do not overlap with previously predicted cholesterol consensus motifs (CCM) (22) or Cholesterol Recognition Amino Acid Consensus (CRAC) motifs (52) identified for other GPCRs, confirming the theory that GPCRs lack predictable primary sequence consensus motifs for cholesterol binding (53, 54)