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additional contraceptive methods may be needed during initiation and dose escalation [19] [20] Bone health monitoring may be advisable, as rapid weight loss can affect bone density Cardiovascular benefits may be particularly relevant given increased cardiovascular risk post-menopause When to contact your healthcare provider: Severe or persistent abdominal pain Persistent vomiting preventing fluid intake Signs of dehydration Symptoms of gallbladder disease Any concerns about medication tolerability Pregnancy must be avoided during treatment, and specific medications (e.g., semaglutide) require discontinuation at least 2 months before planned conception
Additional oral supplementation with polypodium leucotomos extract (PLE) at 480 mg twice daily can be helpful (anecdotal evidence, unpublished)
10.1093/toxres/tfaf024 125 XiaoM.GuoZ.YangY.HuC.ChengQ.ZhangC.et al (2024)
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