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Description

Sexual and appetite effects can show up faster but vary widely from person to person

1 Lesions may be brown or black and may be flat, nodular, or verrucose

Subgroup analyses of CVOTs based on baseline metformin use in two previous meta-analyses, respectively, directed by Brendon L and Apostolos Tsapas have shown that SGLT-2i reduce the risk of MACE, HHF, or CV death, while GLP-1 RAs reduce MACE, cardiovascular mortality, and all-cause mortality regardless of metformin background treatment