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4.1 Overview of clinical studies While animal studies have provided mechanistic support for the involvement of gut microbiota in perioperative neurocognitive regulation, clinical evidence in humans remains limited

If symptoms recur despite repeated pauses or dose reductions, the patients maximum tolerated dose should be accepted as the maintenance dose or switching to a different agent

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While they are generally safe and can be beneficial, its crucial to use them as part of a comprehensive weight loss plan that includes a balanced diet and regular exercise