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64 The stimulatory effects of ATII on the activity of the Nox would suggest that in the presence of an activated reninangiotensin systema common finding during hypertensionincreased vascular oxidative stress is likely to be expected

Taken together, there is no doubt that measurement of endothelial function provides substantial prognostic information about future cardiovascular events in atherosclerotic disease and hypertension, whereas its role in primary prevention and whether the introduction of novel methods to assess endothelial function will further increase its prognostic potential 52 remains to be established