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This study has shown that combining pharmacological ascorbic acid with mFOLFOX6 or FOLFIRI has a significant decrease effect in all-grade and grade 3 bone marrow and gastrointestinal toxic effects (149)

Although pentavalent methylated arsenicals (MAs V , DMAs V , TMAs V ) are less toxic than inorganic ones (iAs V , iAs III ), the trivalent intermediated formed during the methylation process (MAs III , DMAs III ) are much more cytotoxic and genotoxic (Hughes, 2009)

Understanding this pathway matters for interpreting side effects

The incidence is on the order of three to six cases per 10,000 population per year, and prevalence among women is at least 2%