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2 Structure, Distribution, and Physiological Action of the Carnitine Palmitoyltransferase System CPT1, CPT2, and carnitine-acylcarnitine translocase (CACT) play vital roles in the transport system for FA esterification in the mitochondrial membrane
Liu's [187] research in the ApoE-deficient mice indicates that reducing SLC7A11 and GPX4 levels, leading to altered intracellular GSH and iron concentrations in foam cells and decreased macrophage migratory capacity from the intima, thereby promoting the development of AS
Significantly, enhanced transamination and aspartate synthesis in K-Ras-driven cancer cells are important in the promotion of nucleotide biosynthesis 184 and maintenance of redox balance 29
Since TAMs are often skewed toward the M2 phenotype in established tumors, reprogramming or repolarizing them from the tumor-promoting M2 type to the tumor-suppressing M1 type can inhibit tumor progression and enhance the efficacy of immunotherapies
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