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Impaired FAD-dependent enzyme activity is also detrimental to bloodbrain barrier (BBB) integrity, leading to downregulation of tight-junction proteins such as claudin-5 and occluding, increased permeability, and enhanced peripheral immune infiltration

Figure 1 In addition, we have pointed to many beneficial pleiotropic effects of DPP-4 inhibitors with protective role in renal and cardiovascular disorders as specific entities or type 2 diabetes mellitus associated comorbidities including myocardial regeneration

GLP-1 receptor agonists are not indicated for type 1 diabetes