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Methods Materials Required for Drug Preparation Soybean lecithin, DSPE-PEG2000 and DSPE-PEG2000-Maleimide was purchased from Xian Ruixi Biological Technology Co., Ltd, oridonin from MCE, and DCM from Sigma-Aldrich

In addition, skin sections were stained with Massons trichrome (TC) stain to evaluate collagen deposition and dermal structure

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The discovery, preclinical, and early clinical development of potent and selective GPR40 agonists for the treatment of type 2 diabetes mellitus (LY2881835, LY2922083, and LY2922470)