Regulatory status differences Epithalamin is approved in Russia for treatment of menopause-related symptoms, anovulatory infertility, and hormone-dependent tumors
The intense inflammatory response seen in AF and the effectiveness of TNF-alpha inhibitors in treating similar chronic inflammatory skin conditions, including plaque psoriasis and hidradenitis suppurativa, have led to the off-label use of these medications by dermatologists for treatment-resistant acne (45, 46)
In addition to its genomic effects, ATRA can also act through non-canonical mechanisms, for example, by interacting with the aldehyde dehydrogenase (ALDH) enzyme family or modulating the immune response, potentially with a pro-tumorigenic role (31, 3335)
However, DULs long-term efficacy and safety need to be further studied