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In hypertension, GAS5 is significantly downregulated in endothelial cells (ECs) and VSMCs, and its silencing exacerbates vascular remodeling, increases capillary leakage, and promotes endothelial dysfunction by modulating -catenin signaling

The study compared three administration routes intraperitoneal, oral (in drinking water), and topical (thin cream layer) all delivered without a carrier

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263 Senescent cell-based cancer therapies include the induction of senescence in tumor cells and the subsequent selective elimination of senescent cells