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While in the foregoing specification this invention has been described in relation to certain embodiments thereof, and many details have been put forth for the purpose of illustration, it will be apparent to those skilled in the art that the invention is susceptible to additional embodiments and that certain of the details described herein can be varied considerably without departing from the basic principles of the invention

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Linagliptin, however, uses a distinct elimination route, as the majority of the drug is eliminated through the hepatobiliary system and, thus, is more favorable in cases of renal dysfunction [31]

For Type 2 patients, one answer is to search for a drug that controls blood-sugar levels in a similar way to insulin, but is more convenient to use