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These obstacles are there to control costs , not to improve patient outcomes

It has been documented that nuclear-cytoplasmic translocation of HMGB1 in LPS-treated macrophages depended on its phosphorylation by cPKC or calcium/calmodulin-dependent protein kinase IV (CaMKIV) (7072)

Since the microbiome contributes to systemic immunity and can metabolise certain drugs, this may represent an indirect mechanism affecting both host susceptibility to TB and the bioavailability of orally administered anti-TB agents (Fan et al., 2023

14 Prophylactic systemic antibiotics should be avoided unless a workup for infection raises concern for bacterial superinfection