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Although the paper does not outline specific criteria for identifying patients who might deteriorate significantly, some combination of dose ingested, time of ingestion, specific form of VPA involved (long-acting preparations pose an increased risk of continued delayed absorption), serum VPA level on presentation, and symptoms should be considered

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Thankfully, in recent years there have been more treatment options available to people struggling with obesity

The post says some people see significant benefit and good tolerability at 10 mg or lower, and that pushing toward the ceiling without clinical justification may add side-effect burden for no additional gain