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Alcohol adds empty calories, can worsen nausea and interferes with blood-sugar control

In the chronic inflammatory environment of tophi, MGCs play essential roles in maintaining granuloma stability and sustaining immune activation

Do not crush, cut, or chew XR tablets, because that can alter the release pattern

In terms of its effects, it appears to impact drinking in ways (though not necessarily mechanisms) similar to naltrexone (FDA-approved) and topiramate (prescribed off label for alcohol use disorder), which have a greater effect in reducing intensity of drinking on drinking days relative to their effects on whether someone drinks at all (i.e., abstinent days) although all of them do increase abstinent days to some degree on average)