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In brief, the protocol consists of the following steps: (1) generation of flexible regions in FOXO4 FH (residues 86-104 and 186-207), the p53 TAD2 peptide, and spin labels, randomization of the flexible regions

doi: 10.3389/fgene.2021.647246 129 KalinowskiALilientalJAnkerLALinkovskiOCulbertsonCHallJNet al

Owing to the overproduced H 2 O 2 and GSH in tumor cells, TeNW can selectively eliminate cancer cells while normal cells survive (Figure 1J)

However, several clinical studies have shown that increasing glutathione (GSH) may be beneficial post chemotherapy by lessening the side effects of these particularly toxic drugs [10, 11]