Furthermore, it can be hypothesized that GLP-1 RAs reduce atherosclerotic plaque vulnerability in diabetes by promoting sirtuin 6 (SIRT6) expression, increases in collagen content, adiponectin secretion, and its anti-inflammatory effects through adaptor protein PH domain and leucine zipper containing 1 (APPL1) signaling pathways ( In addition to direct actions in coronary arteries, GLP-1 RAs can prevent the formation and progression of coronary atherosclerosis through indirect mechanisms, such as maintaining glycemic control, losing weight, decreasing systolic blood pressure, obtaining beneficial effects from lipid levels, inhibiting platelet activation, reducing systemic inflammation and levels of circulating BNP (Sun et al., 2015a, 2015b
If approved, patients receive a personalized plan that includes dosing guidance and safety information
10.1111/appy.12120 [DOI] [PubMed] [Google Scholar] 88.Kerling A, Kck M, Tegtbur U, Grams L, Weber-Spickschen S, Hanke A, et al
Patients should pair medications with a healthy lifestyle for best results
