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Empagliflozin in Heart Failure: Notably, empagliflozin has demonstrated efficacy in treating heart failure, including in patients with a preserved ejection fractiona condition where the heart muscle contracts normally but the ventricles do not fill with enough blood

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Mechanistically, L-tryptophan upregulated the expression of GLP-1related genes (e.g., Gcg and Pcsk1 ) in intestinal L cells, further promoting GLP-1 production (Jiang et al., 2024)