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Description

Symptoms include: Reduced ability to detect familiar odors

Clinical pharmacology studies show gastric half-emptying time increases from roughly 90 minutes at baseline to 150180 minutes on therapeutic doses

In these cases, a lower-dose approach may allow partial receptor engagement while clinicians monitor symptoms and metabolic markers

Patient 2 started receiving methotrexate at a significantly higher level than the other patients, and their weight-based dose was equivalent to 13.4 units/kg of glucarpidase