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It is clear that neither X-ray crystallography nor cryo-EM can obtain a high resolution structure for intrinsically disordered proteins (IDPs) and intrinsically disordered regions (IDRs) because of a very simple reason: unlike ordered, well-folded proteins and domains, IDPs/IDRs do not adopt a single, stable three-dimensional structure

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But many advisers who voted "yes" to greenlight the peptides for compounding argued that doing so would lead to a safer pathway through which people could access the drugs

PLoS ONE 10:e0136468 Zhao X et al (2019) Benefits of vitamins in the treatment of Parkinsons disease