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Clinicians should titrate the benzodiazepine to clinical effect, with the goal of patient sedation and maintenance of normal vital signs

Research also indicates crosstalk between the ISR pathway and activation of mTORC1 and AKT, with mitophagy partially mediated by ATF4 expression induced by eIF2a phosphorylation [189]

Thamer Alessa has received research grants from Servier

48 Ex vivo studies have shown that ketamine (1 mmol/L) applied to human urothelial cells generates dose-related cytotoxic effects by inducing the intrinsic apoptotic pathway