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Aside from the structural and functional defects observed within the tumor vasculature, tumor blood vessels are molecularly distinct from normal vessels since they respond to environmental cues by transcriptional regulation of gene expression [91,92,93,94,95,96,97,98,99]

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By aligning only potentially substrate binding residues we get a more relevant analysis of the SLC25 family with respect to substrate binding as these structures are expected to be more variable and better indicators of shared transport activities