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Compared with placebo, CIT significantly blunted increases in systolic blood pressure, pulse pressure, and forward and backward pressure waves, indicating a reduction in arterial pulsatile load under stress conditions

Chen Y, Chen B, Wu T et al (2023) Cryo-EM structure of human -opioid receptor-Gi complex bound to an endogenous agonist dynorphin A

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In contrast, the male physiology is characterized by a particular stable hormonal variation, which is more suitable for the brain research experiments 2,3