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When TSC1/TSC2 is phosphorylated by AKT1 it is less effective at stimulating the GTPase activity of Rheb and therefore Rheb activation of mTOR will remain high as is the case in response to insulin action

doi: 10.1016/j.jbc.2023.105577 Ashwood, Lauren M., Elnahriry, Khaled A., Stewart, Zachary K., Shafee, Thomas, Naseem, Muhammad Umair, Szanto, Tibor G., van der Burg, Chlo A., Smith, Hayden L., Surm, Joachim M., Undheim, Eivind A

A place where mitochondrial trouble occurs frequently is the brain [108]

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