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Their discussion in longevity contexts is grounded in mechanistic reasoning rather than dedicated longevity trials

That does not mean GLP-1 adoption automatically damages PepsiCo

They can help stabilize blood sugar levels and reduce cravings, which work in tandem with the appetite-regulating effects of GLP-1 medication

Thus, although informative, BiFC studies at the cytosolic face of the ER seem problematic, as previously shown by the analyses of proteins involved in ER-plasma membrane tethering in plant cells (Tao et al., Overexpression of polytopic membrane proteins often results in clustering at the ER, especially when enforced by dimerization via split YFP reconstitution, which we exploited for GPT1 in Baune et al