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Furthermore, an altered bone metabolism that is caused by androgen excess is evident in PCOS

Its primary strengths lie in brightening skin tone, reducing dark spots, and providing antioxidant protection against environmental damage

Notably, AHCY is the only reversible enzyme in the methionine cycle and as such is a key regulator of the SAM to SAH molar ratio, commonly referred to as the methylation index or indicator of methylation capacity. [67] When SAH and homocysteine concentrations increase faster than methionine regeneration, SAM utilizing enzymes are inhibited by SAH and the SAM concentrations then act in a feed-forward mechanism to allosterically activate the B6-dependent cystathionine beta-synthase (CBS) which metabolizes homocysteine through the transsulfuration pathway and allows the methionine cycle to continue [68,69]

It is important to note, however, that the therapeutic efficacy of MSCs is undoubtedly multifaceted